Genome-wide perturbations by miRNAs map onto functional cellular pathways, identifying regulators of chromatin modifiers.

Tyler J MossZijun LuoElena G SeviourVasudha SehgalYiling LuSteven M HillRajesha RupaimooleJu-Seog LeeCristian Rodriguez-AguayoGabriel Lopez-BeresteinAnil K SoodRobert AzencottJoe W GraySach MukherjeeGordon B MillsPrahlad T Ram

Published in: NPJ systems biology and applications (2015)

Mapping of miRNA-induced protein and phosphoprotein changes onto pathways revealed new miRNA-cellular pathway connectivity, paving the way for targeting of dysregulated pathways with potential miRNA-based therapeutics.

Keyphrases

genome wide
dna methylation
transcription factor
dna damage
small molecule
high glucose
single cell
white matter
copy number
drug induced
multiple sclerosis
protein protein
drug delivery
mass spectrometry