Proinflammatory polarization of monocytes by particulate air pollutants is mediated by induction of trained immunity in pediatric asthma.

Hesam MovassaghMary M PrunickiAbhinav KaushikXiaoying ZhouDiane DunhamEric M SmithZiyuan HeGerman R Aleman MuenchMinyi ShiAnnika K WeimerShu CaoSandra AndorfAmir FeiziMichael P SnyderPejman SorooshElizabeth D MellinsKari Christine Nadeau

Published in: Allergy (2023)

The specific alterations of monocytes after ambient pollution exposure suggest a possible prognostic immune signature for pediatric asthma, and pollution-induced trained immunity may provide a potential therapeutic target for asthmatic children living in areas with increased air pollution.

Keyphrases

air pollution
lung function
particulate matter
heavy metals
chronic obstructive pulmonary disease
human health
risk assessment
resistance training
dendritic cells
health risk assessment
peripheral blood
high glucose
young adults
cystic fibrosis
allergic rhinitis
climate change
body composition