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Neuropathology of genetically defined malformations of cortical development-A systematic literature review.

Stefanie BrockFilip CoolsAnna C Jansen
Published in: Neuropathology and applied neurobiology (2021)
Neuropathological data in patients with MCD with a defined genetic cause are available only for a small number of genes. As each genetic cause might lead to unique histopathological features of MCD, standardised thorough neuropathological assessment and reporting should be encouraged. Histological features can help improve the understanding of the pathogenesis of MCD and generate hypotheses with impact on further research directions.
Keyphrases
  • dna methylation
  • genome wide
  • copy number
  • gene expression
  • electronic health record
  • big data
  • emergency department
  • adverse drug
  • bioinformatics analysis