Neuropathology of genetically defined malformations of cortical development-A systematic literature review.

Stefanie BrockFilip CoolsAnna C Jansen

Published in: Neuropathology and applied neurobiology (2021)

Neuropathological data in patients with MCD with a defined genetic cause are available only for a small number of genes. As each genetic cause might lead to unique histopathological features of MCD, standardised thorough neuropathological assessment and reporting should be encouraged. Histological features can help improve the understanding of the pathogenesis of MCD and generate hypotheses with impact on further research directions.

Keyphrases

dna methylation
genome wide
copy number
gene expression
electronic health record
big data
emergency department
adverse drug
bioinformatics analysis