Aorta-specific DNA methylation patterns in cell-free DNA from patients with bicuspid aortic valve-associated aortopathy.
Ashna MarediaDavid GuzzardiMohammad AleinatiFatima IqbalArshroop KhairaAiswarya MadhuXuemei WangAlex J BarkerPatrick M McCarthyPaul W M FedakSteven C GreenwayPublished in: Clinical epigenetics (2021)
In a cohort of patients undergoing surgery for BAV-associated aortopathy, elevated WSS created by abnormal flow hemodynamics was associated with increased aortic wall cell death which supports the use of aorta-specific cfDNA as a potential tool to identify aortopathy and stratify patient risk.
Keyphrases
- aortic valve
- aortic stenosis
- transcatheter aortic valve replacement
- transcatheter aortic valve implantation
- cell death
- aortic valve replacement
- dna methylation
- patients undergoing
- minimally invasive
- gene expression
- coronary artery bypass
- case report
- genome wide
- pulmonary artery
- signaling pathway
- left ventricular
- cell proliferation
- atrial fibrillation
- copy number
- pulmonary hypertension
- percutaneous coronary intervention