Trans-ethnic genomic informed risk assessment for Alzheimer's disease: An International Hundred K+ Cohorts Consortium study.

Patrick M SleimanHui-Qi QuJohn J ConnollyFrank MentchAlexandre PereiraPaulo A LotufoStephen TollmanAnanyo ChoudhuryMichele RamsayNorihiro KatoKouichi OzakiRisa MitsumoriJae-Pil JeonChang Hyung HongSang Joon SonHyun Woong RohDong-Gi LeeNaaheed MukadamIsabelle F FooteCharles R MarshallAdam ButterworthBram P PrinsJoseph T GlessnerHakon H Hakonarsonnull null

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

As the initial effort by the IHCC to leverage existing large-scale datasets in a collaborative setting with DAC, we developed a trans-ethnic GIRA for AD with the potential of identifying individuals at high risk of developing AD for future clinical applications.

Keyphrases

risk assessment
human health
heavy metals
cognitive decline
quality improvement
copy number
current status
rna seq
climate change
single cell
genome wide