Toll-like receptors 2 and 7 mediate coagulation activation and coagulopathy in murine sepsis.

Brittney WilliamsJessica NederPing CuiAndrew SuenKenichi TanakaLin ZouWei Chao

Published in: Journal of thrombosis and haemostasis : JTH (2019)

Murine sepsis leads to an increased procoagulant response, thrombocytopenia, and global coagulopathy. TLR2 and TLR7 play an important role in procoagulant production and in SIC.

Keyphrases

toll like receptor
septic shock
inflammatory response
acute kidney injury
intensive care unit
immune response
nuclear factor