Serial single-cell profiling analysis of metastatic TNBC during Nab-paclitaxel and pembrolizumab treatment.
Jiehui DengAatish ThennavanSuhagi ShahEce BagdatliogluNatalie KlarAdriana HeguyChristian MarierPeter MeynYutong ZhangKristen LabbeChristina AlmonteMichelle KrogsgaardCharles M PerouKwok-Kin WongSylvia AdamsPublished in: Breast cancer research and treatment (2020)
Our study provides a deep cellular analysis of on-treatment changes during chemo-immunotherapy for advanced TNBC, demonstrating not only feasibility of single-cell analyses on serial tumor biopsies but also the heterogeneity of TNBC and differences in on-treatment changes in responder versus progressor.