Comparative Study of Sonodynamic and Photoactivated Cancer Therapies with Re(I)-Tricarbonyl Complexes Comprising Phenanthroline Ligands.
Rajesh KushwahaVirendra SinghSilda PetersAshish Kumar YadavTumpa SadhukhanBiplob KochSamya BanerjeePublished in: Journal of medicinal chemistry (2024)
Herein, we have compared the effectivity of light-based photoactivated cancer therapy and ultrasound-based sonodynamic therapy with Re(I)-tricarbonyl complexes ( Re1 - Re3 ) against cancer cells. The observed photophysical and TD-DFT calculations indicated the potential of Re1 - Re3 to act as good anticancer agents under visible light/ultrasound exposure. Re1 did not display any dark- or light- or ultrasound-triggered anticancer activity. However, Re2 and Re3 displayed concentration-dependent anticancer activity upon light and ultrasound exposure. Interestingly, Re3 produced 1 O 2 and OH • on light/ultrasound exposure. Moreover, Re3 induced NADH photo-oxidation in PBS and produced H 2 O 2 . To the best of our knowledge, NADH photo-oxidation has been achieved here with the Re(I) complex for the first time in PBS. Additionally, Re3 released CO upon light/ultrasound exposure. The cell death mechanism revealed that Re3 produced an apoptotic cell death response in HeLa cells via ROS generation. Interestingly, Re3 showed slightly better anticancer activity under light exposure compared to ultrasound exposure.
Keyphrases
- cell death
- magnetic resonance imaging
- ultrasound guided
- contrast enhanced ultrasound
- cancer therapy
- visible light
- healthcare
- drug delivery
- computed tomography
- density functional theory
- stem cells
- oxidative stress
- nitric oxide
- hydrogen peroxide
- risk assessment
- climate change
- single cell
- drug induced
- papillary thyroid
- reactive oxygen species
- electron transfer
- smoking cessation