The proportion of alveolar type 1 cells decreases in murine hypoplastic congenital diaphragmatic hernia lungs.
Tram Mai NguyenJulio JimenezLinda Elowsson RendinCatharina MüllerGunilla Westergren-ThorssonJan A DeprestJaan ToelenPublished in: PloS one (2019)
The mouse nitrofen/bisdiamine model is a potential model allowing the study of congenital diaphragmatic hernia lung development from early stages using a wide array of methods. Based on this model, the alveolar epithelium showed a decrease in the number of alveolar type 1 cell in congenital diaphragmatic hernia lungs while type 2 cell population remains unchanged.