Persistence, Magnitude, and Patterns of Postacute Symptoms and Quality of Life Following Onset of SARS-CoV-2 Infection: Cohort Description and Approaches for Measurement.
Michael J PelusoJ Daniel KellyScott LuSarah A GoldbergMichelle C DavidsonSujata MathurMatthew S DurstenfeldMatthew A SpinelliRebecca HohViva TaiEmily A FehrmanLeonel TorresYanel HernandezMeghann C WilliamsMireya I ArreguinLynn H NgoMonika DeswalSadie E MunterEnrique O MartinezKhamal A AnglinMariela D RomeroJacqueline TavsPaulina R RugartJessica Y ChenHannah M SansVictoria W MurrayPayton K EllisKevin C DonohueJonathan A MassachiJacob O WeissIrum MehdiJesus Pineda-RamirezAlex F TangMegan A WengerMelissa T AssenzioYan YuanMelissa R KroneRachel L RutishauserIsabel Rodriguez-BarraquerBryan GreenhouseJohn A SaucedaMonica GandhiAaron Wolfe SchefflerPriscilla Y HsueTimothy J HenrichSteven G DeeksJeffrey N MartinPublished in: Open forum infectious diseases (2021)
Many participants report bothersome symptoms following onset of COVID-19 with variable patterns of persistence and impact on quality of life. The substantial variability suggests the existence of multiple subphenotypes of PASC. A rigorous approach to the prospective measurement of symptoms and functional manifestations sets the stage for the next phase of research focusing on the pathophysiologic causes of the various subgroups of PASC.