Combined effects of ovariectomy and streptozotocin-induced diabetes in the articular cartilage of rats.

A Saeki FernandesC C N FonsecaG Rodrigues da Silva SassoL Carvalho CezarM Aparecida Dos SantosM J SimõesRicardo Dos Santos SimõesR Florencio-Silva

Published in: Climacteric : the journal of the International Menopause Society (2017)

Our results indicate that the combination of ovariectomy and streptozotocin-induced diabetes produces more deleterious effects in articular cartilage of rats than either condition alone.

Keyphrases

diabetic rats
oxidative stress
type diabetes
high glucose
cardiovascular disease
high fat diet
glycemic control
diabetic nephropathy
bone loss
drug induced
skeletal muscle