Absence of Resistance Mutations in the Integrase Coding Region among ART-Experienced Patients in the Republic of the Congo.
Ferdinand Emaniel Brel GotPatricia Recordon-PinsonGhislain Loubano-VoumbiDagene EbourombiMarie-Lise BlondotMathieu MétifiotGontran OndzottoMarie-Line AndreolaPublished in: Microorganisms (2021)
We confirmed a high diversity of HIV-1 in the Republic of the Congo. Most patients presented an accumulation of mutations conferring resistance against NRTIs, NNRTIs and PIs. Nonetheless, the absence of integrase mutations associated with drug resistance suggests that the introduction of integrase inhibitors into therapy will be highly beneficial to patients in the Republic of the Congo.