GATA3 Exerts Distinct Transcriptional Functions to Regulate Radiation Resistance in A549 and H1299 Cells.

Rui Wang Junxuan Yi Hui Gao Xinfeng Wei Lihong Shao Mingwei Wang Weiqiang Xu Xiaoshu Yin Yan Nan Shen Zhicheng Wang Wei Wei Shunzi Jin

Published in: Oxidative medicine and cellular longevity (2022)

GATA3, an upstream transcriptional regulator of NRP1 gene, regulates the radioresistance of A549 and H1299 cells by opposite mechanisms, which provides a new target for radiotherapy of lung cancer.

Keyphrases

transcription factor
induced apoptosis
cell cycle arrest
gene expression
early stage
endoplasmic reticulum stress
signaling pathway
oxidative stress
cell death
squamous cell carcinoma
copy number
dna methylation
locally advanced