Genetic Determined Iron Starvation Signature in Friedreich's Ataxia.

Manuel GranderDavid HaschkaElisabetta IndelicatoChristian KremserMatthias AmprosiWolfgang NachbauerBenjamin HenningerAmbra StefaniBirgit HöglChristine FischerMarkus SeifertStefan KiechlGünter WeissSylvia Boesch

Published in: Movement disorders : official journal of the Movement Disorder Society (2024)

We provide evidence for a previously unrecognized iron starvation signature at systemic and cellular levels in FA patients, which is related to the underlying genetic severity. These findings challenge the use of systemic iron lowering therapies in FA. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

end stage renal disease
iron deficiency
genome wide
chronic kidney disease
newly diagnosed
prognostic factors
copy number
peritoneal dialysis
systematic review
gene expression
dna methylation