PFKFB3 works on the FAK-STAT3-SOX2 axis to regulate the stemness in MPM.

Sayantani Sarkar BhattacharyaPrabhu ThirusanguLing JinJulie StaubViji Shridhar Julian R Molina

Published in: British journal of cancer (2022)

This study confers a comprehensive and mechanistic function of PFKFB3 in CSC maintenance that may foster exceptional opportunities for targeted small molecule blockade of the TICs in MPM.

Keyphrases

small molecule
stem cells
epithelial mesenchymal transition
transcription factor
cell proliferation
cancer therapy
signaling pathway
cell migration