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Untangling the web of intratumour heterogeneity.

Zheqi LiMarco SeehawerKornelia Polyak
Published in: Nature cell biology (2022)
Intratumour heterogeneity (ITH) is a hallmark of cancer that drives tumour evolution and disease progression. Technological and computational advances have enabled us to assess ITH at unprecedented depths, yet this accumulating knowledge has not had a substantial clinical impact. This is in part due to a limited understanding of the functional relevance of ITH and the inadequacy of preclinical experimental models to reproduce it. Here, we discuss progress made in these areas and illuminate future directions.
Keyphrases
  • single cell
  • papillary thyroid
  • healthcare
  • squamous cell
  • current status
  • stem cells
  • squamous cell carcinoma
  • childhood cancer
  • mesenchymal stem cells