Role of FK506 Binding Protein on Tacrolimus Distribution in Red Blood Cells.
Naoki YoshikawaTsubasa YokotaAyako MatsuoNobuhiro MatsumotoTomomi IwakiriRyuji IkedaPublished in: Pharmaceutical research (2020)
FKBP played an important role in the distribution of tacrolimus in RBCs. The effect of intracellular and extracellular FKBPs on RBC distribution of tacrolimus in circulating blood was substantial. FKBP was shown as a potential biomarker for predicting the pharmacokinetics and pharmacodynamics of tacrolimus.
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