Beyond the Risk of Biofilms: An Up-and-Coming Battleground of Bacterial Life and Potential Antibiofilm Agents.
Mohamed M ZeineldinAhmed EsmaelRashad R Al-HindiMona G AlharbiDebebe Ashenafi BekeleAddisu D TeklemariamPublished in: Life (Basel, Switzerland) (2023)
Microbial pathogens and their virulence factors like biofilms are one of the major factors which influence the disease process and its outcomes. Biofilms are a complex microbial network that is produced by bacteria on any devices and/or biotic surfaces to escape harsh environmental conditions and antimicrobial effects. Due to the natural protective nature of biofilms and the associated multidrug resistance issues, researchers evaluated several natural anti-biofilm agents, including bacteriophages and their derivatives, honey, plant extracts, and surfactants for better destruction of biofilm and planktonic cells. This review discusses some of these natural agents that are being put into practice to prevent biofilm formation. In addition, we highlight bacterial biofilm formation and the mechanism of resistance to antibiotics.
Keyphrases
- biofilm formation
- candida albicans
- staphylococcus aureus
- pseudomonas aeruginosa
- microbial community
- induced apoptosis
- escherichia coli
- primary care
- healthcare
- cell cycle arrest
- human health
- type diabetes
- oxidative stress
- antimicrobial resistance
- endoplasmic reticulum stress
- cell proliferation
- metabolic syndrome
- adipose tissue
- gram negative
- signaling pathway
- pi k akt
- glycemic control