RNA editing in cancer impacts mRNA abundance in immune response pathways.

Tracey W ChanTing FuJae Hoon BahnHyun-Ik JunJae-Hyung LeeGiovanni Quinones-ValdezChonghui ChengXinshu Grace Xiao

Published in: Genome biology (2020)

Our study reports widespread differences in RNA editing between epithelial and mesenchymal tumors and a novel mechanism of editing-dependent regulation of mRNA abundance. It reveals the broad impact of RNA editing in cancer and its relevance to cancer-related immune pathways.

Keyphrases

crispr cas
papillary thyroid
immune response
squamous cell
stem cells
bone marrow
nucleic acid
antibiotic resistance genes
lymph node metastasis
squamous cell carcinoma
binding protein
emergency department
childhood cancer
wastewater treatment
drug induced