Human subarachnoid space width oscillations in the resting state.
Marcin GruszeckiGemma LancasterAneta StefanovskaJ Patrick NearyRyan T DechWojciech GuminskiAndrzej F FrydrychowskiJacek KotPawel J WinklewskiPublished in: Scientific reports (2018)
Abnormal cerebrospinal fluid (CSF) pulsatility has been implicated in patients suffering from various diseases, including multiple sclerosis and hypertension. CSF pulsatility results in subarachnoid space (SAS) width changes, which can be measured with near-infrared transillumination backscattering sounding (NIR-T/BSS). The aim of this study was to combine NIR-T/BSS and wavelet analysis methods to characterise the dynamics of the SAS width within a wide range of frequencies from 0.005 to 2 Hz, with low frequencies studied in detail for the first time. From recordings in the resting state, we also demonstrate the relationships between SAS width in both hemispheres of the brain, and investigate how the SAS width dynamics is related to the blood pressure (BP). These investigations also revealed influences of age and SAS correlation on the dynamics of SAS width and its similarity with the BP. Combination of NIR-T/BSS and time-frequency analysis may open up new frontiers in the understanding and diagnosis of various neurodegenerative and ageing related diseases to improve diagnostic procedures and patient prognosis.
Keyphrases
- resting state
- functional connectivity
- blood pressure
- multiple sclerosis
- cerebrospinal fluid
- photodynamic therapy
- endothelial cells
- end stage renal disease
- drug release
- fluorescence imaging
- newly diagnosed
- ejection fraction
- heart rate
- metabolic syndrome
- minimally invasive
- working memory
- prognostic factors
- single cell
- case report
- adipose tissue
- peritoneal dialysis
- machine learning
- drug delivery
- weight loss
- blood brain barrier
- induced pluripotent stem cells