Janus kinase inhibitor overcomes resistance to immune checkpoint inhibitor treatment in peritoneal dissemination of gastric cancer in C57BL/6 J mice.

Wan-Ying DuHiroki MasudaKoji NagaokaTomohiko YasudaKomei KugeYasuyuki SetoKazuhiro KakimiSachiyo Nomura

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2024)

Dual ICI treatment exerts its anti-tumor effects by increasing tumor-specific CD8 + T cell infiltration, and the addition of JAKi further improves ICI resistance by reshaping the immunosuppressive TME.

Keyphrases

type diabetes
metabolic syndrome
adipose tissue
skeletal muscle
combination therapy
high fat diet induced