Magic spot nucleotides: tunable target-specific chemoenzymatic synthesis.

Thomas M HaasPaul EbenspergerVerena B EisenbeisChristoph NopperTobias Dürr-MayerNikolaus JorkNicole SteckClaudia Jessen-TrefzerHenning Jacob Jessen

Published in: Chemical communications (Cambridge, England) (2019)

A tunable chemoenzymatic strategy provides access to the entire class of magic spot nucleotides and modified analogues. The approach combines chemoselective bisphosphorylations using phosphoramidites with regioselective ribonuclease T2 cyclo-phosphate hydrolysis, leading to flexible and simple gram-scale operations.

Keyphrases

solid state
gram negative
energy transfer
molecular docking
light emitting
multidrug resistant
structure activity relationship