Chemotherapy alters the increased numbers of myeloid-derived suppressor and regulatory T cells in children with acute lymphoblastic leukemia.
Mohamed Labib SalemMohamed Ramadan El-ShanshorySaid Mohamed AbdouMohamed S AttiaShymaa M SobhyMona F ZidanAbdel-Aziz A ZidanPublished in: Immunopharmacology and immunotoxicology (2018)
Our results indicate that B-ALL patients harbor high numbers of both MDSCs and Tregs cells. This pilot study opens a new avenue to investigate the mechanism mediating the emergence of these cells on larger number of B-ALL patients at different treatment stages.
Keyphrases
- regulatory t cells
- induced apoptosis
- acute lymphoblastic leukemia
- cell cycle arrest
- end stage renal disease
- ejection fraction
- newly diagnosed
- endoplasmic reticulum stress
- dendritic cells
- oxidative stress
- prognostic factors
- young adults
- immune response
- cell death
- squamous cell carcinoma
- signaling pathway
- patient reported outcomes
- locally advanced
- cell proliferation
- rectal cancer
- combination therapy