The consequences of viral infection on host DNA damage response: a focus on SARS-CoVs.
Asmaa S MekawyZina AlaswadAya A IbrahimAhmed A MohamedAbdelrahman AlOkdaMenattallah ElserafyPublished in: Journal, genetic engineering & biotechnology (2022)
DNA damage and genome instability in host cells are introduced by many viruses during their life cycles. Severe acute respiratory syndrome coronaviruses (SARS-CoVs) manipulation of DNA damage response (DDR) is an important area of research that is still understudied. Elucidation of the direct and indirect interactions between SARS-CoVs and DDR not only provides important insights into how the viruses exploit DDR pathways in host cells but also contributes to our understanding of their pathogenicity. Here, we present the known interactions of both SARS-CoV and SARS-CoV-2 with DDR pathways of the host cells, to further understand the consequences of infection on genome integrity. Since this area of research is in its early stages, we try to connect the unlinked dots to speculate and propose different consequences on DDR mechanisms. This review provides new research scopes that can be further investigated in vitro and in vivo, opening new avenues for the development of anti-SARS-CoV-2 drugs.
Keyphrases
- sars cov
- dna damage response
- induced apoptosis
- dna damage
- cell cycle arrest
- dna repair
- respiratory syndrome coronavirus
- oxidative stress
- cell death
- endoplasmic reticulum stress
- genome wide
- escherichia coli
- staphylococcus aureus
- mass spectrometry
- drug induced
- atomic force microscopy
- single molecule
- candida albicans
- solid phase extraction