Macrophages expressing TREM-1 are involved in the progression of HPV16-related oropharyngeal squamous cell carcinoma.

Barbara AzzimontiLuca RaimondoDiletta Francesca SquarzantiTiziana RossoPaola ZanettaPaolo Aluffi VallettiLuigi ChiusaLaura MasiniGiancarlo PecorariMario AiroldiMarco KrengliMirella GiovarelliGuido Valente

Published in: Annals of medicine (2021)

While p16 shows to better stratify HPV16+ patients' outcome, TREM-1+ macrophages suggest their key importance in HPV-related OP-SCCs progression.KEY MESSAGESTREM-1 positivity correlates to the worst overall survival of HPV16-positive OPSCCs-affected patients.p16-positive HPV16 related OPSCCs patients have a better prognosis with respect to p16-negative ones.

Keyphrases

end stage renal disease
squamous cell carcinoma
newly diagnosed
ejection fraction
chronic kidney disease
high grade
prognostic factors