ROS Suppression by Egg White Hydrolysate in DOCA-Salt Rats-An Alternative Tool against Vascular Dysfunction in Severe Hypertension.
Edina da Luz AbreuCamila Rodrigues MoroSamia Hassan Husein KanaanRicardo Bernardino de PaulaCamila Teixeira HerreraPedro Henrique Dorneles CostaFranck Maciel PeçanhaDalton Valentim VassalloLuciana Venturini RossoniMarta Miguel CastroGiulia Alessandra WiggersPublished in: Antioxidants (Basel, Switzerland) (2022)
This study aimed to evaluate the potential for lowering blood pressure and beneficial effects on mesenteric resistance arteries (MRA) and conductance vessels (aorta) produced by dietary supplementation of an egg white hydrolysate (EWH) in rats with severe hypertension induced by deoxycorticosterone plus salt treatment (DOCA-salt), as well as the underlying mechanisms involved. The DOCA-salt model presented higher blood pressure, which was significantly reduced by EWH. The impaired acetylcholine-induced relaxation and eNOS expression observed in MRA and aorta from DOCA-salt rats was ameliorated by EWH. This effect on vessels (MRA and aorta) was related to the antioxidant effect of EWH, since hydrolysate intake prevented the NF-κB/TNFα inflammatory pathway and NADPH oxidase-induced reactive oxygen species (ROS) generation, as well as the mitochondrial source of ROS in MRA. At the plasma level, EWH blocked the higher ROS and MDA generation by DOCA-salt treatment, without altering the antioxidant marker. In conclusion, EWH demonstrated an antihypertensive effect in a model of severe hypertension. This effect could be related to its endothelium-dependent vasodilator properties mediated by an ameliorated vessel's redox imbalance and inflammatory state.
Keyphrases
- blood pressure
- reactive oxygen species
- oxidative stress
- hypertensive patients
- dna damage
- diabetic rats
- cell death
- heart rate
- drug induced
- contrast enhanced
- aortic valve
- pulmonary artery
- high glucose
- rheumatoid arthritis
- signaling pathway
- metabolic syndrome
- endothelial cells
- computed tomography
- anti inflammatory
- type diabetes
- body mass index
- coronary artery
- magnetic resonance
- immune response
- cell proliferation
- insulin resistance
- pi k akt
- physical activity
- breast cancer cells
- combination therapy
- weight gain
- pulmonary arterial hypertension
- single molecule
- arterial hypertension
- toll like receptor
- human health