Novel preclinical murine model of trauma-induced elbow stiffness.

Stephanie N Moore-LotridgeWilliam K OelsnerYael IhejirikaMihir J DesaiSandra S GebhartJonathan G Schoenecker

Published in: Journal of experimental orthopaedics (2018)

A soft tissue injury to the peri-elbow soft tissue with a concomitant deficiency in plasminogen, instigates elbow stiffness and pathologic features similar to those observed in humans. This pre-clinical model is valuable for translational studies designed to investigate the contributions of pathologic features to elbow stiffness or as a high-throughput model for testing therapeutic strategies designed to prevent and treat trauma-induced elbow stiffness.

Keyphrases

soft tissue
high throughput
high glucose
neoadjuvant chemotherapy
stem cells
trauma patients
endothelial cells
mesenchymal stem cells
rectal cancer