Diagnostic accuracy of serum matrix metalloproteinase-7 as a biomarker of biliary atresia in a large North American cohort.

Sindhu Pandurangi Reena Mourya Shreya Nalluri Lin Fei Shun Dong Sanjiv Harpavat Stephen L Guthery Jean P Molleston Philip Rosenthal Ronald J Sokol Kasper S Wang Vicky Lee Ng Estella M Alonso Katelyn M Saarela Saul J Karpen Kathleen M Loomes John C Magee Benjamin L Shneider Simon Peter Horslen Jeffrey H Teckman Jorge A Bezerranull null

Published in: Hepatology (Baltimore, Md.) (2024)

Serum MMP-7 has high discriminative properties to differentiate BA from other forms of neonatal cholestasis. MMP-7 cutoff values vary according to assay technology. Using MMP-7 in the evaluation of infants with cholestasis may simplify diagnostic algorithms and shorten the time to hepatoportoenterostomy.

Keyphrases

cell migration
machine learning
drug induced
high throughput
deep learning