Chymotrypsin activity signals to intestinal epithelium by protease-activated receptor-dependent mechanisms.
Simon GuignardMahmoud SaifeddineKoichiro MiharaMajid MotahharyMagali SavignacLaura GuiraudDavid SagnatMireille SebbagSokchea KhouCorinne RollandAnissa EdirBarbara BournetLouis BuscailEtienne BuscailLaurent AlricCaroline CamareMouna AmbliNathalie VergnolleMorley D HollenbergCéline DeraisonChrystelle BonnartPublished in: British journal of pharmacology (2024)
Our results highlight the ability of chymotrypsin to signal to intestinal epithelial cells via PARs, which may have important physiological consequences in gut homeostasis.
Keyphrases