CNP Promotes Antiarrhythmic Effects via Phosphodiesterase 2.
Eleder CachorroMario GünschtMario SchubertMirna S SadekJohanna SiegertFabian DuttCarla BauermeisterSusann QuickertHenrick BerningFelix NowakowskiSimon LämmleRebecca FirneburgXiaojing LuoStephan R KünzelErik KlapprothPeter MirtschinkManuel MayrMatthias DewenterChristiane VettelJordi HeijmanKristina LorenzKaomei GuanAli El-ArmoucheMichael WagnerSusanne KämmererPublished in: Circulation research (2023)
CNP shows strong PDE2-dependent antiarrhythmic effects. Consequently, the CNP-PDE2 axis represents a novel and attractive target for future antiarrhythmic strategies.
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