Transcriptional comparison of testicular adrenal rest tumors with fetal and adult tissues.
Mariska A M SchröderFred C G J SweepAntonius E van HerwaardenRod T MitchellJitske EliveldAns M M van PeltAlan E RowanDarren KorbieNike M M L StikkelbroeckHedi L Claahsen-van der GrintenPaul N SpanPublished in: European journal of endocrinology (2022)
Our data suggest that TART is induced - most likely via activation of a cAMP/protein kinase A-dependent receptor - from a progenitor cell into a unique mature adrenal-like cell type, sometimes exhibiting both adrenal and testicular features.