Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma.

Chanbora CheaMutsumi MiyauchiToshihiro InubushiNurina Febriyanti AyuningtyasAjiravudh SubarnbhesajPhuong Thao NguyenMadhu ShresthaSivmeng HaingKouji OhtaTakashi Takata

Published in: PloS one (2018)

This is the first report showing that bLF selectively suppresses proliferation through mTOR/S6K and JAK/STAT3 pathways and induction of apoptosis in OSCC. This study provides important new findings, which might be useful in the prevention and treatment of OSCC.

Keyphrases

signaling pathway
oxidative stress
cell death
cell proliferation
combination therapy
pi k akt
smoking cessation