Effective termination of atrial fibrillation by SK channel inhibition is associated with a sudden organization of fibrillatory conduction.

Giulia GattaVladimir Sobota Carlotta Citerni Jonas Goldin DinessUlrik S SørensenThomas Jespersen Bo Hjorth Bentzen Stef ZeemeringMarion KuiperSander Verheule Ulrich Schotten Arne van Hunnik

Published in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2022)

AP14145 provided a successful therapy for termination of persistent AF in goats. During AF, AP14145 caused an ERP and AF cycle length prolongation. AP14145 slowed CV during fast pacing but did not lead to a further decrease during AF. Termination of AF was preceded by an abrupt organization of AF with a decline in the number of fibrillation waves.

Keyphrases

atrial fibrillation
oral anticoagulants
catheter ablation
left atrial
left atrial appendage
direct oral anticoagulants
transcription factor
heart failure
percutaneous coronary intervention
left ventricular
cardiac resynchronization therapy
venous thromboembolism