[68Ga]Ga-NODAGA-E[(cRGDyK)]2 PET and hyperpolarized [1-13C] pyruvate MRSI (hyperPET) in canine cancer patients: simultaneous imaging of angiogenesis and the Warburg effect.

Andreas ClemmensenAdam E HansenPernille HolstChristina SchøierSissel BisgaardHelle H JohannesenJan Henrik Ardenkjær-LarsenAnnemarie T KristensenAndreas Kjaer

Published in: European journal of nuclear medicine and molecular imaging (2020)

We demonstrated combined imaging of [68Ga]Ga-NODAGA-RGD-PET for angiogenesis and hyperpolarized [1-13C]pyruvate-MRSI for probing energy metabolism. The results suggest that [68Ga]Ga-NODAGA-RGD-PET and [1-13C]pyruvate-MRSI may provide complementary information, indicating that hyperPET imaging of angiogenesis and energy metabolism is able to aid in cancer phenotyping, leading to improved therapy planning.

Keyphrases

pet ct
positron emission tomography
high resolution
endothelial cells
vascular endothelial growth factor
computed tomography
stem cells
mass spectrometry
young adults
molecular dynamics simulations
lymph node metastasis