Impact of folic acid on regulatory B lymphocytes from patients with systemic lupus erythematosus in vitro.
Kalina Nikolova-GanevaVasil VasilevSimona KerezievaAndrey TchorbanovPublished in: International journal of rheumatic diseases (2022)
The observed increase may be a consequence of additional indirect or direct methylation of DNA in specific loci of the targeted cells. However, further analysis would clarify the exact mechanism of action of folate and would reveal its immunomodulating potential in this autoimmune disease.
Keyphrases
- genome wide
- induced apoptosis
- cell cycle arrest
- dna methylation
- multiple sclerosis
- circulating tumor
- cancer therapy
- transcription factor
- single molecule
- cell free
- single cell
- endoplasmic reticulum stress
- density functional theory
- cell death
- oxidative stress
- signaling pathway
- genome wide association study
- drug induced
- risk assessment