Cobalt-Catalyzed Four-Component Carbonylation of Methylarenes with Ethylene and Alcohols.
Jian-Xing XuChang-Sheng KuaiXiao-Feng WuPublished in: The Journal of organic chemistry (2022)
Direct conversion of raw materials to fine chemicals is greatly economically influential. We developed a non-expensive cobalt-catalyzed multicomponent carbonylative reaction for the synthesis of γ-aryl carboxylic acid esters from readily available methylarene, ethylene, and CO, which are widely found in multiple FDA-approved drugs.