Frontoparietal-Striatal Network and Nucleus Basalis Modulation in Patients With Parkinson Disease and Gait Disturbance.
Akira NishidaAtsushi ShimaDaisuke KambeKoji FurukawaHaruhi Sakamaki-TsukitaKenji YoshimuraIkko WadaYusuke SakatoYuta TeradaMasanori SawamuraEtsuro NakanishiYosuke TarunoHodaka YamakadoYasutaka FushimiTomohisa OkadaYuji NakamotoRyosuke TakahashiNobukatsu SawamotoPublished in: Neurology (2024)
These findings suggest that the functional connectivity of the FPN with the caudate, as mediated by the cholinergic Ch4 projection system, underlies the compensatory recruitment of attention and executive function for damaged automaticity in gait in patients with PD.