Therapeutic effects of Tanshinone IIA and Tetramethylpyrazine nanoemulsions on cognitive impairment and neuronal damage in Alzheimer's disease rat models.
Liang FangHongyan ChengWeidong ChenCan PengYuanxu LiuCaiyun ZhangPublished in: The Journal of pharmacy and pharmacology (2024)
TSN/TMP O/W NEs can inhibit MAPK/ERK/CREB signaling pathway and effectively alleviate cognitive impairment, oxidative stress injury, and neuronal apoptosis in AD rats.
Keyphrases
- oxidative stress
- cognitive impairment
- signaling pathway
- pi k akt
- induced apoptosis
- cell cycle arrest
- diabetic rats
- ischemia reperfusion injury
- dna damage
- cerebral ischemia
- epithelial mesenchymal transition
- cell proliferation
- cognitive decline
- endoplasmic reticulum stress
- blood brain barrier
- subarachnoid hemorrhage