Intracellular K + limits T cell exhaustion and preserves antitumor function.
Camille CollierKelly WuchererMatthew McWhorterChelsea JenkinsAlexandra BartlettRahul RoychoudhuriRobert EilPublished in: bioRxiv : the preprint server for biology (2023)
and promotes ROS accumulation, tonic signal transduction and T cell exhaustion owing to ROS accumulation. Engineering T cell ion transport is an important consideration for cancer immunotherapy.