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Intracellular K + limits T cell exhaustion and preserves antitumor function.

Camille CollierKelly WuchererMatthew McWhorterChelsea JenkinsAlexandra BartlettRahul RoychoudhuriRobert Eil
Published in: bioRxiv : the preprint server for biology (2023)
and promotes ROS accumulation, tonic signal transduction and T cell exhaustion owing to ROS accumulation. Engineering T cell ion transport is an important consideration for cancer immunotherapy.
Keyphrases
  • reactive oxygen species
  • cell death
  • dna damage
  • oxidative stress