Cystathionine β-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis.

Yu-Fu ZhouShu-Shu SongMeng-Xin TianZheng TangHan WangYuan FangWei-Feng QuXi-Fei JiangChen-Yang TaoRun HuangPei-Yun ZhouShi-Guo ZhuJian ZhouJia FanWei-Ren LiuYing-Hong Shi

Published in: Journal for immunotherapy of cancer (2022)

Our results indicate the antitumor function of CBS in HCC by inactivation of the PRRX2/IL-6/STAT3 pathway, which may serve as a potential target for HCC clinical immunotherapy.

Keyphrases

cell proliferation
climate change