Hypoxia-induced polypoid giant cancer cells in glioma promote the transformation of tumor-associated macrophages to a tumor-supportive phenotype.
Yuyang LiuYing ShiMengwan WuJialin LiuHong WuChuan XuLing ChenPublished in: CNS neuroscience & therapeutics (2022)
PGCCs promote malignancy and immune-suppressive microenvironment in GBM. PGCCs or their progeny cells may be a potential therapeutic target for GBM.