Generalizability of Tau and Amyloid Plasma Biomarkers in Alzheimer's Disease Cohorts of Diverse Genetic Ancestries.

Anthony J GriswoldFarid RajabliTianjie GuJamie ArvizuCharles G GolightlyPatrice L WhiteheadKara L Hamilton-NelsonLarry D AdamsJose Javier SanchezPedro R MenaTakiyah D StarksMaryenela Illanes-ManriqueConcepcion SilvaWilliam S BushMichael L CuccaroJeffery M VanceMario R Cornejo-OlivasBriseida E Feliciano-AstacioGoldie S ByrdGary W BeechamJonathan L HainesMargaret A Pericak-Vance

Published in: medRxiv : the preprint server for health sciences (2024)

pTau-181 as a plasma biomarker for clinical AD is generalizable across genetic ancestries, but predictive value may differ. Combining genomic and biomarker data from diverse individuals will increase understanding of genetic risk and refine clinical diagnoses.

Keyphrases

copy number
genome wide
electronic health record
cognitive decline
dna methylation
gene expression
big data
data analysis
mild cognitive impairment