IGF2BP3 mediates the mRNA degradation of NF1 to promote triple-negative breast cancer progression via an m6A-dependent manner.

Xu ZhangLiang ShiHan-Dong SunZi-Wen WangFeng XuJi-Fu WeiQiang Ding

Published in: Clinical and translational medicine (2023)

TET3-mediated IGF2BP3 accelerated the proliferation of TNBC by destabilising NF1 mRNA via an m6A-dependent manner. This suggests that IGF2BP3 could be a potential therapeutic target for TNBC.

Keyphrases

pi k akt
signaling pathway
binding protein
lps induced
growth hormone
cell proliferation
oxidative stress
nuclear factor
immune response