BRCA1 and PALB2 in a Messy Breakup.
Joonyoung HerSamuel F BuntingPublished in: Cancer research (2021)
Mutations in the BRCA1 gene cause an extremely high lifetime risk of breast and ovarian cancer, but the exact mechanism by which the BRCA1 protein acts to prevent cancer onset remains unclear. In this edition of Cancer Research, Park and colleagues describe a new mouse model featuring a single amino acid substitution in the coiled-coil motif of BRCA1. This change prevents BRCA1 from interacting with PALB2 (partner and localizer of BRCA2), causing rapid cancer onset and a loss of blood cells similar to Fanconi anemia.See related article by Park et al., p. 4172.
Keyphrases
- papillary thyroid
- mouse model
- breast cancer risk
- amino acid
- gene expression
- induced apoptosis
- squamous cell carcinoma
- lymph node metastasis
- oxidative stress
- childhood cancer
- small molecule
- genome wide
- cell proliferation
- young adults
- density functional theory
- protein protein
- men who have sex with men
- cell cycle arrest
- iron deficiency