The CD98 Heavy Chain Is a Marker and Regulator of Head and Neck Squamous Cell Carcinoma Radiosensitivity.
David DigomannIna KurthAnna TyutyunnykovaOleg ChenSteffen LöckIelizaveta GorodetskaClaudia PeitzschIra-Ida SkvortsovaGiulia NegroBertram AschenbrennerGraeme EisenhoferSusan RichterStephan HeidenJoseph PorrmannBarbara KlinkChristian SchwagerAdam A DowleLinda HeinLeoni A Kunz-SchughartAmir AbdollahiFabian LohausMechthild KrauseMichael BaumannAnnett LingeAnna DubrovskaPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
We found that CD98hc-associated signaling mechanisms play a central role in the regulation of HNSCC radioresistance and may be a promising target for tumor radiosensitization.