Hepatitis E virus infection activates NOD-like receptor family pyrin domain-containing 3 inflammasome antagonizing interferon response but therapeutically targetable.
Yang LiPeifa YuAmy L KesslerJingyi ShuXiaoyan LiuZhaochao LiangJiaye LiuYunlong LiPengfei LiLing WangYining WangZhongren MaAixia LiuLing WangMarco J BrunoRobert A de ManMaikel P PeppelenboschSonja I BuschowLin WangYijin WangMaikel P PeppelenboschPublished in: Hepatology (Baltimore, Md.) (2021)
HEV infection strongly activates NLRP3 inflammasome activation in macrophages, which regulates host innate defense and pathogenesis. Therapeutic targeting of NLRP3, in particular when combined with antiviral agents, represents a viable option for treating severe HEV infection.