Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage.
Ellen G AveryHendrik BartolomaeusAriana RauchChia-Yu ChenGabriele N'DiayeUlrike LoeberTheda Ulrike Patricia BartolomaeusRaphaela Fritsche-GuentherAndré Felipe RodriguesAlex YarrituCheng ZhongLingyan FeiDmitry TsvetkovMihail TodirasJoon-Keun ParkLajos MarkóAndrás MaifeldAndreas PatzakMichael BaderStefan KempaJennifer A KirwanSofia Kirke Forslund-StartcevaDominik N MullerNicola WilckPublished in: Cardiovascular research (2022)
To assess the potential of microbiota-targeted interventions to prevent organ damage in hypertension, an accurate quantification of microbial influence is necessary. We provide evidence that the development of hypertensive organ damage is dependent on colonization status and suggest that a healthy microbiota provides anti-hypertensive immune and metabolic signals to the host. In the absence of normal symbiotic host-microbiome interactions, hypertensive damage to the kidney in particular is exacerbated. We suggest that hypertensive patients experiencing perturbations to the microbiota, which are common in CVD, may be at a greater risk for target-organ damage than those with a healthy microbiome.