Cancer type and histology influence cutaneous immunotherapy toxicities: a multi-institutional cohort study.
Guihong WanSara KhattabBonnie W LeungShijia ZhangNga NguyenMatthew TranChuck LinCrystal T ChangNora AlexanderRuple JairathJordan PhillippsKimberly TangAhmad RajehLeyre ZubiriSteven T ChenShadmehr DemehriKun-Hsing YuAlexander GusevShawn G KwatraNicole R LeBoeufKerry L ReynoldsYevgeniy R SemenovPublished in: The British journal of dermatology (2024)
The highest rate of cirAEs and subsequent survival benefits were observed in cutaneous malignancies treated with ICI therapies. This study improves our understanding of patients who are at highest risk of developing cirAEs and would, therefore, benefit from appropriate counselling and closer monitoring by their oncologists and dermatologists throughout their ICI therapy. Limitations include its retrospective nature and cohort from one geography.