Picroside II suppresses chondrocyte pyroptosis through MAPK/NF-κB/NLRP3 signaling pathway alleviates osteoarthritis.

Fanchen WangJiacong XiaoMiao LiQi HeXintian WangZhaofeng PanShaocong LiHaibin WangChi Zhou

Published in: PloS one (2024)

Our research suggests that Picroside II can inhibit chondrocyte pyroptosis and ameliorate osteoarthritis progression by modulating the MAPK/NF-κB signaling pathway.

Keyphrases

signaling pathway
pi k akt
nlrp inflammasome
induced apoptosis
rheumatoid arthritis
epithelial mesenchymal transition
knee osteoarthritis
oxidative stress
cell proliferation
lps induced
inflammatory response
endoplasmic reticulum stress
nuclear factor