Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes.

Laura J AndreasenRikke K KirkChristian FledeliusMark A Yorek Jens LykkesfeldtThorbjorn Akerstrom

Published in: Journal of diabetes research (2020)

In summary, our data suggest that high-dose insulin treatment attenuates small nerve fiber damage. Furthermore, data also indicate that both poor glycemic control and dyslipidemia are associated with disease progression. Consequently, this rat model of T2D seems to fit well with progression of DPN in humans and could be a relevant preclinical model to use in relation to research investigating treatment opportunities for DPN.

Keyphrases

type diabetes
glycemic control
high dose
cardiovascular disease
low dose
stem cells
metabolic syndrome
combination therapy
bone marrow
adipose tissue
cell therapy
deep learning
skeletal muscle
stem cell transplantation
artificial intelligence
smoking cessation